![]() ![]() ![]() The researchers found that pregnant people who received the COVID-19 vaccines generated antibodies against specific types of SARS-CoV-2. The researchers also analyzed participants’ cord blood at the time of birth. Researchers examined blood samples taken before and after participants were vaccinated or boosted, and at time of delivery. Results from 240 participants are reported in this paper, including 167 pregnant participants who received the two-dose primary series of either of the two mRNA vaccines during pregnancy, and 73 who received a booster dose at the time, only one booster dose was recommended. ![]() Researchers at the NIAID-funded Infectious Diseases Clinical Research Consortium (IDCRC) followed more than 500 pregnant volunteers and their newborns, at nine study sites. Among other metrics, the study tracked the COVID-19 antibody levels of pregnant people who received either of the two COVID-19 vaccines, as well as the antibodies in their cord blood when they gave birth. Researchers also suspected that, as with other vaccines, the antibodies generated by COVID-19 vaccination might transfer to fetuses across the placenta, which would provide newborns with some additional protection against COVID-19 in their first months of life. Pregnant people are more likely to be hospitalized and die from severe COVID-19, and the disease puts them at greater risk for preterm birth. Researchers hoped to understand the immune response following receipt of Pfizer and Moderna COVID-19 vaccines, and determine how much protection against illness they provided. The MOMI-VAX study launched in June 2021 when data on COVID-19 vaccination in pregnant people were sparse. The paper describes results from the Multisite Observational Maternal and Infant Study for COVID-19 (MOMI-VAX), which was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Receiving a COVID-19 mRNA vaccine or booster during pregnancy can benefit pregnant people and their newborn infants, according to findings recently published in Vaccine. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Colorized scanning electron micrograph of a cell (pink) infected with the Omicron strain of SARS-CoV-2 virus particles (teal), isolated from a patient sample. ![]()
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